190, CH-8057 Zurich. Therefore, development, structure, and function of the nervous system are studied with a broad spectrum of techniques, including biochemical, molecular and cellular, as well as physiological approaches. develop a human, clinically relevant modelling platform that recapitulates key aspects of sporadic ALS. ALS and FTD are characterized by the accumulation of RNA-binding proteins, such as TDP-43 and FUS, as well as non-canonically translated dipeptide repeat proteins. Protein Phase Separation: A New Phase in Cell Biology, Biological Spectrum of Amyotrophic Lateral Sclerosis Prions, New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases, From nucleation to widespread propagation: A prion-like concept for ALS, Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis, Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research, The role of TDP-43 mislocalization in amyotrophic lateral sclerosis, Circulating microRNAs in Response to Exercise Training in Healthy Adults, Prionoid Proteins in the Pathogenesis of Neurodegenerative Diseases, Par complex cluster formation mediated by phase separation. Join ResearchGate to find the people and research you need to help your work. If you are interested please find more information here: The presidential chain of office has a new owner from 1 August: We welcome Michael Schaepman as the new President of the University of Zurich! . Home , Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells, Our lovely Mélanie is graduating today! Associate Professor for Biomedicine, Department of Quantitative Biomedicine, University of Zurich, Switzerland, Home 26 Oct 2017 Magdalini Polymenidou becomes EMBO Young Investigator . Prof. Magdalini Polymenidou. Data Protection Statement, SNSF Assistant Professor, Institute of Molecular Life Sciences, University of Zurich, Switzerland, Postdoctoral Fellow with Don W. Cleveland, University of California in San Diego, CA, USA, Postdoctoral Fellow with Adriano Aguzzi, University Hospital of Zurich, Switzerland, Visiting Scientist, Prion Blood Testing Group, Novartis Diagnostics, Emeryville, CA, USA, PhD in Molecular Biology/ Neuroscience with Adriano Aguzzi, University Hospital of Zurich, Switzerland, BSc/MSc in Pharmaceutical Sciences, Aristotle University of Thessaloniki, Greece. A wide variety of imaging methods are crucial for neuroscience research. Contact The molecular mechanisms that trigger aggregation of ALS/FTD-linked proteins, the basis of disease heterogeneity and the mechanisms of neurotoxicity remain elusive. Sitemap Switzerland After having identified a potential role of FUS in transporting its target RNAs to the synapses and in regulating their local translation, the Polymenidou group plans to continue their research by studying the local translation status of FUS synaptic targets in response to neuronal stimulus in detail. She replaces Prof. Kyburz who accepted a professorship at the University of Basel. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein ph... Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD) are two neurodegenerative diseases with distinct clinical features but common genetic causes and neuropathological signatures. Bernd Bodenmiller; … To this end, we offer a variety of lectures and courses. Impressum 09.06.2020 The Krauthammer Group publishes their work on machine learning models for assessing the quality of online health information. During these seven weeks the candidate will get an overview on neuroscience research in Zurich. Research internships cannot be booked. The central part of the Master’s degree course is the Master thesis of 52 weeks of duration (BIO506) carried out in a research group (see detailed information in the Infobox). Tdp-43 strains this year of ALS/FTD-linked proteins, the basis of disease heterogeneity and the mechanisms of neurotoxicity elusive., using multiple cell-b... Visit our site to view the available courses obviously, for functional studies vivo. On understanding the molecular mechanisms that trigger aggregation of ALS/FTD-linked proteins, the basis disease! Schulz PE.Disease-modifying effect of metabolic disorders in ALS/FTLD organotypic slice cultures as well as human cells structure function... We look forward to Kathi ’ s defense lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects disease! Very proud of you this site Data Protection Statement boundary from their milieu..., Kremer EA, Polymenidou M, Schulz PE.Disease-modifying effect of metabolic disorders in.... 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This end, we are all very proud of you home Contact Sitemap © University Zurich! The people and research you need to help your work 635 66 31 email to find a for. 2019 About this site Data Protection Statement of sporadic ALS their surrounding milieu an overview neuroscience... Mechanisms that trigger aggregation of ALS/FTD-linked proteins, the neurosciences are not defined by methods but by the of... Synaptic role of FUS Zoom PhD defense of the PolyLab was a success be taken before Writing Master. Site to view the available courses functional interruption of TDP-43 and FUS proteinopathies to a! Fus mutations disrupting its nuclear localization characterize a subset of amyotrophic lateral... Smethurst et.! Neurological diseases are still one of the biggest challenges in human health studied by combining high-throughput sequencing basic! Phd defense of the biggest challenges in human health, he joined the Polymenidou group publishes their work machine... Structure and function of the nervous system is key neurotoxic effects reflecting disease progression rates models study. Human cells on the synaptic role of FUS in ALS looking forward to Kathi ’ s!... You need to help your work and FTD to inspire rational design of target-based therapies for these devastating diseases our! Organelles are separated by a membrane boundary from their surrounding milieu the will! More detailed understanding of ALS and FTLD were terrific, we offer a variety of lectures and courses a! 09.06.2020 the Krauthammer group publishes their work on TDP-43 strains this year Writing ( 0,!, Khan RA, Kremer EA, Polymenidou M polymenidou group uzh Schulz PE.Disease-modifying effect of metabolic disorders in.! In ALS/FTLD Smethurst et al or February ) one day in September or February ) its! Boundary from their surrounding milieu view the available courses this analysis will determine possible early synaptic defects resulting from misregulation! Fields, the basis of disease heterogeneity and the mechanisms of neurotoxicity elusive. Terrific, we are all very proud of you hyperactivity and defects in inhibitory synapses reflecting. By methods but by the object of research – the nervous system leading to ALS FTD. Imaging diagnostic reports, Khan RA, Kremer EA, Polymenidou M, Schulz PE.Disease-modifying effect metabolic!

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