The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 (TA1) are reviewed. We carried out cost-effectiveness analysis using the institutional perspective, including a 45-year time frame and a 3% discount rate for costs and effectiveness. We employed a Bayesian-focused decision tree and a Markov model. Thymosin alpha1, an immunomodulatory endogenous peptide, has been shown to be effective in the treatment of chronic hepatitis B and C. In this study, single- and 5-day multiple-dose pharmacokinetics were characterized in nine Caucasian volunteers after subcutaneous administration of 900 microg/m2 thymosin alpha1. You must declare any conflicts of interest related to your comments and responses. It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 (TA1) are reviewed. To comment please, Comments on Medscape are moderated and should be professional in tone and on topic. [5] With a mass of 3108 daltons, the polypeptide has the following amino acid sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser- Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu- Lys-Glu-Lys-Lys-Glu-Val-Val-Glu- Glu-Ala-Glu-Asn-OH. https://doi.org/10.1016/j.arcmed.2005.11.010. You will receive email when new content is published. C. David Ancell, Jerry Phipps, and Linda Young. Triple therapy (peginterferon plus ribavirin plus thymosin alpha-1) was dominant with lower cost and higher utility in relationship with peginterferon + ribavirin option, peginterferon alone and no-treatment option. You've successfully added to your alerts. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Energetics investigation on encapsulation of protein/peptide drugs in carbon nanotubes. Zadaxin thymosin alpha 1 (thymalfasin) Injection is an amino acid peptide used to treat hepatitis B.Many people taking Zadaxin do not experience side effects. One- and two-way sensitivity analyses were performed, as well as threshold-oriented and probabilistic analyses, and we obtained acceptability curves and net health benefits. C. David Ancell, Pharm.D., is Pharmacist, Nova Factor, Memphis, TN; Jerry Phipps, Pharm.D., is Pharmacist and Owner of City Drug Company, McKenzie, TN; and Linda Young, Pharm.D., is Assistant Professor and Director, University of Tennessee Drug Information Center, Memphis, TN. Please enter a Recipient Address and/or check the Send me a copy checkbox. Contraindications can include nursing and pregnant women, and an individual being deliberately immunocompromised. 2001;58(10) © 2001 American Society of Health-System Pharmacists. If you log out, you will be required to enter your username and password the next time you visit. Thymosin α 1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene.. Click the topic below to receive emails when new articles are available. Published by Elsevier Inc. All rights reserved. Current hypotheses consider Thymosin Alpha-1 to be the main constituent of Thymosin Fraction-5, and as such it is considered to be the active component that restores the immune function in both athymic animals and animals with dysfunctional thymus glands. Copyright © 2006 IMSS. Hepatitis C Virus Therapies: Current Treatments, Targets and Future Perspectives, Ribonucleic Acid Viruses: Antivirals for Influenza A and B, Hepatitis C Virus, and Respiratory Syncytial Virus, Filled carbon nanotubes in biomedical imaging and drug delivery. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. TA1 is a synthetic polypeptide. Common side effects of Zadaxin include redness and discomfort at the injection site, muscle atrophy, multiple joint aches and pains, and swelling and rash of the hand.. We use cookies to help provide and enhance our service and tailor content and ads. OBJECTIVE TA1, or thymalfasin (Zadaxin, SciClone Pharmaceuticals), is a chemically synthesized polypeptide that is identical to human TA1. Burnout Might Really Be Depression; How Do Doctors Cope? OBJECTIVE Thymosin alpha1, an immunomodulatory endogenous peptide, has been shown to be effective in the treatment of chronic hepatitis B and C. In this study, single- and 5-day multiple-dose pharmacokinetics were characterized in nine Caucasian volunteers after subcutaneous administration of 900 microg/m2 thymosin alpha1.

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