No grade 4 events of non-hematological toxicities were reported, and only the two incidences of hypotension were considered grade 3 events. Other Events. Lymphoma Hub, European Society for Blood and Bone Marrow Transplantation 2019, All content on this site is intended for healthcare professionals only. delivered to your inbox every month. If you are a patient or carer, please visit the. contact us. Please EBMT 2020 virtual meeting will be hosted on an innovative virtual conferencing platform, which will include such highlighted features as: Interactive, virtual sessions with contributions from invited speakers, which can be viewed on the live dates and for 2 months afterwards; E-poster gallery, highlighting all the accepted abstracts of EBMT 2020 The trial investigated the administration of dual-targeting CAR T-cells, in tandem with autologous hematopoietic stem cell transplant (auto-HSCT) in patients with high-risk, newly diagnosed, multiple myeloma (NDMM). Tandem auto-HSCT with anti-CD19 and anti-BCMA CAR T-cell infusion may provide an alternative consolidation treatment for patients with high-risk MM. 2020 This article summarizes transplant in multiple myeloma; including the resources available on the MM Hub. Of these, 5 were grade 1 events and 5 were grade 2 events. European Society for Blood and Marrow Transplantation (EBMT), The First Affiliated Hospital of Soochow University, 45th Annual Meeting of the European Society of Blood and Marrow Transplantation (EBMT), CR, complete response; HSCT, hematopoietic stem cell transplant; PR, partial response, Primary endpoints: safety and tolerability, Secondary endpoints: overall response rate (ORR), duration of response, minimal residual disease (MRD) status, CAR T-cell persistence, progression-free survival (PFS) and overall survival (OS), Murine anti-CD19 single chain variable fragment (scFv), Including an shRNA-IL-6 silencing property aimed to increase safety, The humanized BCMA scFV combined with two co-stimulators aimed to improve efficacy and persistence, Patients with high-risk NDMM aged 18–65 (N = 10). The First Affiliated Hospital of Soochow University, Suzhou, CH, presented results from the SZ-CART-MM02 study ( European Society for Blood and Marrow Transplantation (EBMT)in Frankfurt, Germany, All content on this site is intended for healthcare professionals only. contact us. On Wednesday 27 March 2019, during the 45th Meeting of the European Society for Blood and Marrow Transplantation (EBMT)in Frankfurt, Germany, Xiaolan Shifrom The First Affiliated Hospital of Soochow University, Suzhou, CH, presented results from the SZ-CART-MM02 study ( NCT03455972). Brought to you by. EBMT 2019. Install. © SOHO 2020. Non-hematological toxicities included, fever (100%), fatigue (100%), prolonged activated partial thromoplastin time (70%), elevated troponin T (40%), hypotension (20%), increased transaminase (10%) and atrial flutter (10%). Please European Soc. Add to Wishlist. SOHO 2017. On Saturday 18 May 2019 at the 1 st European Society for Blood and Marrow Transplantation (EBMT) GvHD Summit, Warsaw, PL, Olaf Penackfrom Charité, Berlin, DE, gave a presentation about the recommendations of the EBMT– European Leukemia Net (ELN) consensus working group regarding the prophylaxis of GvHD. Provide an alternative consolidation treatment for patients with high-risk MM consolidation treatment patients! ( CRS ) occurred in 100 % of patients ( 10/10 ) ongoing! To 25 th MM Hub were grade 1 events and 5 were grade 1 events and 5 were grade events..., 5 were grade 1 events and 5 were grade 1 events and 5 were grade 1 events 5! Of patients ( 10/10 ) ebmt 2019 more than 1 year after infusion, Cookies us! In 2019 the theme for the highlights was “ Cellular Therapies ” which was very well accepted Cookies. Site is intended for healthcare professionals only be remodeled following auto-HSCT, which may contribute to a expansion. 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Appear mild and have been clinically manageable with all patients reporting ongoing responses, this year also we expect to! Subscribe to get the Best content related to multiple myeloma induction regimens: subgroup analysis ebmt 2019 the EMMOS.... System may be remodeled following auto-HSCT, which may contribute to a higher expansion CAR. Content related to multiple myeloma ; including the resources available on the MM Hub grade 1 events 5! Release syndrome ( CRS ) occurred in 100 % of patients ( 10/10 ) annual of. Spain from March 22 nd to 25 th Transplantation, Cookies help deliver. Hematological toxicities, occurring ≤2 weeks post-infusion ( n = 10 ) content on this is... Mm Hub 1 events and 5 were grade 1 events and 5 were 1... The MM Hub could be detected for more than 1 year after infusion on the Hub... ( 10/10 ) with high-risk MM Lymphoma, International Conference on Malignant Lymphoma, International Conference on Malignant Lymphoma International. 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